PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1

PROTAC-mediated complex of KRAS with VHL/Elongin-B/Elongin-C/Cullin-2/Rbx1 Descriptor: (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Cullin-2, E3 ubiquitin-protein ligase RBX1, ... Authors: Fischer, G, Peter, D, Arce-Solano, S. Deposit date: 2023-10-14 Release date: 2023-12-06 Last modified: 2024-10-02 Method: ELECTRON MICROSCOPY (3.5 Å) Cite: Targeting cancer with small-molecule pan-KRAS degraders. Science, 385, 2024蛋白水解靶向嵌合体（PROTAC）介导的KRAS与希佩尔-林道蛋白（VHL）/延伸蛋白B（Elongin-B）/延伸蛋白C（Elongin-C）/Cullin-2/Rbx1复合物 描述符：(2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-氨基-3-氰基-4-甲基-6,7-二氢-5H-1-苯并噻吩-4-基]-1,2,4-噁二唑-3-基]嘧啶-2-基]-3-甲基-1,4-二氮杂环庚烷-1-基]丁氧基]-1,2,3-三唑-1-基]-3-甲基-丁酰基]-N-[(1R)-1-[4-(4-甲基-1,3-噻唑-5-基)苯基]-2-羟基-乙基]-4-羟基-吡咯烷-2-甲酰胺、Cullin-2、E3泛素蛋白连接酶RBX1…… 作者：Fischer G、Peter D、Arce-Solano S 提交日期：2023-10-14 发布日期：2023-12-06 最后修改日期：2024-10-02 实验方法：电子显微镜（分辨率3.5埃） 引用：《靶向癌症的小分子泛KRAS降解剂》，《科学》，第385卷，2024年