Patient clinical data and mutation rate summary.

a Estimated by linear regression as the slope of CD4 counts against infection time. For R8, although there were few data points for reliably estimating the CD4 decay rate, rapid progression was supported by the observation that the CD4 count dropped to 338 cells/μL within the first year of infection. Full data are shown in S1 Fig, the S1 Data file, and the S2 Data file.
b Average log viral load obtained from all available patient samples taken at least one year postinfection but before the onset of treatment and/or symptoms. R8 had only one available viral load determination. For R9, a viral load determination taken 329 d after infection was included in the calculation to have at least three data points. Full data are shown in S2 Fig, the S1 Data file, and the S2 Data file.
c Rapid progressors were defined as patients showing a CD4 count decay rate greater than 150 cell/μL per y.
Patient clinical data and mutation rate summary.