GO-term enrichment analysis of cellular genes displaying at least 2-fold changes in expression levels between wt and EBNA-3A negative LCLs (p≤0.05).

aGO-term in the “Biological Process” category. In order to highlight major biological themes and to reduce redundancy, similar annotation terms (e.g. “apoptosis” and “programmed cell death”) were grouped together and representative terms were manually selected. Note that a given gene can be annotated to multiple terms, since the gene ontology is structured as a directed acyclic graph.
bnumber of EBNA-3A target genes annotated to the term.
cstatistical measure for enrichment of a given GO-term among differentially regulated genes with respect to the total number of genes assayed and annotated to the term. Functional groups enriched within EBNA-3A target genes were considered as meaningful in case of EASE-scores≤0.01.