Expeditious Synthesis of 2‑Phenylquinazolin-4-amines via a Fe/Cu Relay-Catalyzed Domino Strategy
收藏Figshare2016-02-15 更新2026-04-29 收录
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https://figshare.com/articles/dataset/Expeditious_Synthesis_of_2_Phenylquinazolin_4_amines_via_a_Fe_Cu_Relay_Catalyzed_Domino_Strategy/2200354
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A highly efficient Fe/Cu relay-catalyzed domino protocol has been developed for the synthesis of 2-phenylquinazolin-4-amines from commercially available ortho-halogenated benzonitriles, aldehydes, and sodium azide. This elegant domino process involved consecutive iron-mediated [3 + 2] cycloaddition, copper-catalyzed SNAr, reduction, cyclization, oxidation, and copper-catalyzed denitrogenation sequences. The formed structure is the privileged core in drugs and bioactive molecules.
创建时间：
2016-02-15
