Hepatoblastomas with carcinoma features represent a biological spectrum of aggressive neoplasms in children and young adults

We molecularly characterized a class of histologically aggressive childhood liver cancers and showed that these tumors are clinically aggressive and that their observed histological features are associated with underlying recurrent molecular features. We proposed a diagnostic algorithm to identify these cancers using a combination of histological and molecular features, and our analysis suggested that these cancers may benefit from specialized treatment strategies that may differ from treatment guidelines for hepatoblastomas and hepatocellular carcinomas. 37 HB samples including 10 equivocal HCN NOS, 12 biphasic HCN NOS, 10 HB FPAs, and 5 HBs of older patients with classical HB, were transcriptomically profiled using the nCounter Human PanCancer Pathways Panel (catalog#: xt-cso-HIO360-12) NanoString platform.