Forebrain Eml1 depletion reveals early centrosomal dysfunction causing subcortical heterotopia

The layered structure of the cerebral cortex is formed through a complicated sequence of highly controlled stages during corticogenesis. The perturbation of neuronal migration and cell division during this process can result a rare disorder called as cortical heterotopia. EML1 is a heterotopia associated gene where the perturbations cause heterotopia formation in human as well as in mouse. To elaborate on the EML1 interactome and its disruptions by heterotopia-associated mutation, we performed BioID proximity labeling of EML1 and EML1*T243A, a human SH-associated mutant form of the protein.