Proteins identified from tumor-derived extracellular vesicles using mass spectrometry

Tumor-derived extracellular vesicles (tEVs) are important communication
tools used by tumor cells to impact the function of other cells in the
body. Accumulating evidence indicate that tEVs could impair the ability of
immune cells in effectively attacking cancer cells. In our study, we find
that proteins carried in tEVs are crucial for the immune-suppressive
function of tEVs. In this study, we identified the proteins present in
tEVs isolated from three different tumor cell lines: MCF7, A375, and A549.
Proteins were extracted from the isolated tEVs, digested with trypsin, and
analyzed by LC-MS/MS to identify the proteins. The identified proteins are
listed in this dataset. Among the proteins identified, a total of 321
proteins were shared in all three tEVs, indicating tEVs use a core set of
proteins to exert their suppressive function.