Dataset for "One-Size-Fits-Many: Antisense oligonucleotides for rescuing splicing mutations in hotspot exons"

Scripts and supplementary data related to the manuscript "One-Size-Fits-Many: Antisense oligonucleotides for rescuing splicing mutations in hotspot exons"

geisinger_mapsy_design.tar.gz - Contains the data and scripts used to generate the MaPSy oligo sequences from the Geisinger and ClinVar variant datasets.

geisinger_mapsy_analysis.tar.gz - Contains the data and scripts for mapping the sequencing results of the MaPSy experiments and deriving metrics such as splicing efficiencies and log allelic fold for the oligo species in the processed libraries.

figure_[1,2,3].zip - Contains the scripts to perform the analysis and create the plots presented in the referenced figures