The role of FGF21 in the effects of low protein diet on the transcriptome of aged mouse kidneys

FGF21 is a circulating hormone that is required for metabolic responces and transcriptional changes to protein restriction. In the current study, we observed increased fibrosis and macrophages inflitration into kidney of FGF21 KO mice fed a LP diet compared to NP diet-fed animals, which is not observed in WT mice. The RNAseq experiment was conducted to compare the effect of LP in WT and FGF21 KO mice on renal transcriptome. Comparison of the effect of low protein (LP) on kidney transcriptome in either WT (each 6 samples from NP and LP fed mice) or FGF21 KO mice (each 6 samples from NP and LP fed mice). Normal protein (NP) contain 20% protein, LP contain 5% protein