Fermt1
收藏rgd.mcw.edu2025-03-21 收录
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https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1315646
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资源简介：
Enables actin filament binding activity. Involved in several processes, including positive regulation of cell adhesion; regulation of gene expression; and regulation of signal transduction. Located in focal adhesion. Is expressed in several structures, including alimentary system; genitourinary system; immune system; lung; and skin. Used to study Kindler syndrome. Human ortholog(s) of this gene implicated in Kindler syndrome; telangiectasis; and vesiculobullous skin disease. Orthologous to human FERMT1 (FERM domain containing kindlin 1). [provided by Alliance of Genome Resources, Nov 2024]
赋予肌动蛋白微丝结合活性。参与多种过程，包括细胞粘附的正向调控；基因表达的调控；以及信号转导的调控。位于焦点粘附区域。在多个结构中表达，包括消化系统；泌尿生殖系统；免疫系统；肺部；以及皮肤。用于研究Kindler综合征。该基因的人类直系同源基因与Kindler综合征；蜘蛛痣；和天疱疮性皮肤疾病有关。与人类FERMT1（含FERM结构域的kindlin 1）同源。[由基因组资源联盟提供，2024年11月]
提供机构：
Rat Genome Database
