CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C1=CN(N=C(C1=O)c2ccnn2c3cc(ccc3F)F)c4cc(ccc4)OC(F)(F)F, micromolar IC50=0.047063

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH C1=CN(N=C(C1=O)c2ccnn2c3cc(ccc3F)F)c4cc(ccc4)OC(F)(F)F, micromolar IC50=0.047063 Descriptor: 3-[1-(2,5-difluorophenyl)-1H-pyrazol-5-yl]-1-[3-(trifluoromethoxy)phenyl]pyridazin-4(1H)-one, GLYCEROL, MAGNESIUM ION, ... Authors: Joseph, C, Benz, J, Flohr, A, Rogers-Evans, M, Rudolph, M.G. Deposit date: 2022-02-01 Release date: 2022-10-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Crystal Structure of a human phosphodiesterase 10 complex To be published

人类磷酸二酯酶10（phosphodiesterase 10）与配体C1=CN(N=C(C1=O)c2ccnn2c3cc(ccc3F)F)c4cc(ccc4)OC(F)(F)F的复合物晶体结构，该配体的微摩尔级半最大抑制浓度（IC50）为0.047063。化学描述符：3-[1-(2,5-二氟苯基)-1H-吡唑-5-基]-1-[3-(三氟甲氧基)苯基]哒嗪-4(1H)-酮，体系含甘油（GLYCEROL）、镁离子（MAGNESIUM ION）等。作者：Joseph, C、Benz, J、Flohr, A、Rogers-Evans, M、Rudolph, M.G.。存放日期：2022-02-01；发布日期：2022-10-12；最后修改日期：2024-10-16。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.3埃。引用文献：《人源磷酸二酯酶10复合物晶体结构》，待发表。