Pro-neural transcription factor Six3 has been implicated in neuronal differentiation. We established primary neural stem cell with Six3 overexpression, and utilized CUT&RUN to profile genomic loci bou

NIAID Data Ecosystem50

Master regulators and cofactors of human neuronal cell fate specification identified by CRISPR gene activation screens [CAS_TF_sgASCL1_Screen_AmpliconSeq]. Master regulators and cofactors of human neuronal cell fate specification identified by CRISPR gene activation screens [CAS_TF_sgASCL1_Screen_AmpliconSeq]

神经元细胞命运编程

调控网络分析

Technologies to reprogram cell-type specification have revolutionized the fields of regenerative medicine and disease modeling. Currently, the selection of fate-determining factors for cell reprogramm

NIAID Data Ecosystem60

Genome-wide transcriptional targets of KLF15 in human airway smooth muscle

气道平滑肌转录调控

转录因子靶点

We previously demonstrated that the transcription factor, KLF15, is a glucocorticoid-regulated gene that represses primary human airway smooth muscle (ASM) proliferation. Here, we show that KLF15 also

NIAID Data Ecosystem50

Transcription factors and target genes in PARVA-induced networks.

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