Aspartyl/Asparaginyl beta-hydroxylase (AspH) in complex with Fe, 2-oxoglutarate, succinate and the hydroxylated product of Factor X derived peptide fragment, 12 h O2 exposure

Aspartyl/Asparaginyl beta-hydroxylase (AspH) in complex with Fe, 2-oxoglutarate, succinate and the hydroxylated product of Factor X derived peptide fragment, 12 h O2 exposure Descriptor: Aspartyl/asparaginyl beta-hydroxylase, FE (III) ION, Factor X light chain, ... Authors: de Munnik, M, Brasnett, A, Rabe, P, Brewitz, L, Park, J, Schofield, C.J, Zhou, T. Deposit date: 2024-12-11 Release date: 2025-12-24 Last modified: 2026-03-11 Method: X-RAY DIFFRACTION (2.14 Å) Cite: Structural basis of the promiscuity of the unusual Fe(II) and 2-oxoglutarate dependent human aspartate/asparagine-beta-hydroxylase. Nat Commun, 2026

天冬氨酰/天冬酰胺基β-羟化酶（aspartyl/asparaginyl beta-hydroxylase, AspH）与铁、2-氧戊二酸、琥珀酸以及因子X衍生肽片段的羟化产物形成复合物，经12小时氧气暴露处理。描述项：天冬氨酰/天冬酰胺基β-羟化酶、三价铁离子、因子X轻链……作者：德·穆尼克（M. de Munnik）、布拉斯内特（A. Brasnett）、拉贝（P. Rabe）、布罗维茨（L. Brewitz）、朴（J. Park）、斯科菲尔德（C.J. Schofield）、周（T. Zhou）。存入日期：2024-12-11，发布日期：2025-12-24，最后修改日期：2026-03-11。实验方法：X射线衍射（2.14埃）。引用文献：非常规铁(II)依赖与2-氧戊二酸依赖型人源天冬氨酸/天冬酰胺-β-羟化酶的催化混杂结构基础，《自然·通讯》（Nat Commun），2026年