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Transcriptomic and epigenomic profiling of H3K27me3 demethylases inhibitor GSK-J4 induced changes in colon cancer cells (RNA-Seq)

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NIAID Data Ecosystem2026-03-12 收录
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H3K27me3 demethylases UTX and JMJD3 play vital roles in development and disease, including cancer. Therefore, we systematically investigated the impact of inhibition of these two demethylases using a small molecule inhibitor in colon cancer cells. Overall design: HCT116 colon cancer cells were treated with 15 µm GSK-J4 or veichle for 48 hours and the cells were harvested for analysis as described below.

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2020-09-23
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