Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578)

Candida albicans dihydrofolate reductase complexed with dihydro-nicotinamide-adenine-dinucleotide phosphate (NADPH) and 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE (GW578) Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[(4-METHYLPHENYL)SULFANYL]-2,4-QUINAZOLINEDIAMINE, DIHYDROFOLATE REDUCTASE, ... Authors: Whitlow, M, Howard, A.J, Kuyper, L.F. Deposit date: 2001-03-22 Release date: 2001-04-11 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.82 Å) Cite: X-ray Crystal Structures of Candida albicans Dihydrofolate Reductase: High Resolution Ternary Complexes in Which the Dihydronicotinamide Moiety of NADPH is Displaced by an inhibitor J.Med.Chem., 44, 2001

本数据集为白色念珠菌二氢叶酸还原酶与二氢烟酰胺腺嘌呤二核苷酸磷酸（NADPH）以及5-[(4-甲基苯基)硫基]-2,4-喹唑啉二胺（GW578）形成的复合物。相关描述符包括：2-(N-吗啉代)乙磺酸、5-[(4-甲基苯基)硫基]-2,4-喹唑啉二胺、二氢叶酸还原酶…… 作者：Whitlow, M、Howard, A.J.、Kuyper, L.F. 沉积日期：2001年3月22日，发布日期：2001年4月11日，最后修订日期：2023年8月9日。实验方法：X射线衍射（分辨率1.82埃）。引用文献：《白色念珠菌二氢叶酸还原酶的X射线晶体结构：NADPH的二氢烟酰胺部分被抑制剂取代的高分辨率三元复合物》，发表于《药物化学杂志》（J. Med. Chem.），第44卷，2001年。