IL27RA dimerizes

Interleukin-27 receptor subunit alpha (IL27RA, WSX1) can interact with itself. Co-expression in HEK- 293 cells followed by immunoprecipitation with epitope tag antibodies revealed that IL27RA forms homodimers. Immunoblotting for JAK proteins and Interleukin-6 receptor beta (IL6ST, gp130) did not detect these as part of the IL27RA-containing complex (Pradhan et al. 2010).<br><br>A deletion mutation has been described to enhance homodimeric Interleukin-27 receptor formation (IL27RA/IL27RA) (Lambert et al. 2011).

白介素-27受体亚基α（IL27RA，WSX1）能够与其自身相互作用。通过在HEK-293细胞中实现共表达并随后使用表位标记抗体进行免疫沉淀，发现IL27RA可形成同源二聚体。针对JAK蛋白和白介素-6受体β（IL6ST，gp130）的免疫印迹分析并未将这些蛋白检测为IL27RA包含的复合物的一部分（Pradhan等，2010年）。此外，已有研究表明，缺失突变能够增强白介素-27受体同源二聚体（IL27RA/IL27RA）的形成（Lambert等，2011年）。