From purified naïve B cells from a BENTA patient cohort, we performed differential expression analysis by RNA-seq to show that BENTA B cells exhibit intrinsic defects in B cell differentiation with po

NIAID Data Ecosystem60

Abatacept Restores Dysregulated Transcriptomic and Proteomic Profiling in LRBA Deficiency and CTLA-4 Insufficiency

免疫缺陷疾病

多组学免疫机制分析

This study investigates the effectiveness of abatacept via flow cytometric and multi-omics approaches in treating lipopolysaccharide-responsive beige-like anchor (LRBA) deficiency, an immune disorder

NIAID Data Ecosystem30

Congenital iRHOM2 deficiency causes ADAM17 dysfunction and environmentally directed immunodysregulatory disease [T cells]

免疫缺陷疾病

T细胞转录组

We report a pleiotropic disease due to loss-of-function mutations in RHBDF2, the gene encoding iRHOM2, in 2 kindreds with recurrent infections in different organs. One patient had recurrent pneumonia

NIAID Data Ecosystem70

Inherited human c-Rel deficiency disrupts myeloid and lymphoid immunity to a variety of infectious agents

免疫缺陷疾病

感染免疫学

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series.

NIAID Data Ecosystem60