Dephosphorylation of p130 (RBL2) by PP2A

Dephosphorylation of p130 (RBL2) by PP2A complex containing either PPP2R3B (B" beta) or PPP2R2A (B alpha) regulatory subunit plays a role in maintaining the equilibrium of hyperphosphorylated and hypophosphorylated p130 (RBL2), through counteracting action of cyclin dependent kinases (CDKs). It is assumed that PP2A dephosphorylates p130 (RBL2) on all three phosphorylation sites, but further experiments are needed to confirm this.

PP2A复合物，由PPP2R3B（Bβ）或PPP2R2A（Bα）调控亚基组成，对p130（RBL2）的去磷酸化作用在维持超磷酸化和低磷酸化p130（RBL2）的平衡中发挥着重要作用，这是通过对抗性调节周期依赖性激酶（CDKs）的活性实现的。据推测，PP2A在p130（RBL2）的三个磷酸化位点上都进行去磷酸化，但需要进一步的实验来验证这一假设。