Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide

Crystal structure of Bcl-Xl complex with 4-(5-butyl-3-(hydroxymethyl)-1-phenyl-1h-pyrazol-4-yl)-3-(3,4-dihydro-2(1h)-isoquinolinylcarbonyl)-n-((2-(trimethylsilyl)ethyl)sulfonyl)benzamide Descriptor: 4-[5-butyl-3-(hydroxymethyl)-1-phenyl-1H-pyrazol-4-yl]-3-(3,4-dihydroisoquinolin-2(1H)-ylcarbonyl)-N-{[2-(trimethylsilyl)ethyl]sulfonyl}benzamide, Bcl-2-like protein 1, IMIDAZOLE Authors: Schroeder, G.M, Wei, D, Banfi, P, Cai, Z, Lippy, J, Menichincheri, M, Modugno, M, Naglich, J, Penhallow, B, Perez, H.L, Sack, J, Schmidt, R.J, Tebben, A, Yan, C, Zhang, L, Galvani, A, Lombardo, L.J, Borzilleri, R.M. Deposit date: 2012-04-03 Release date: 2012-06-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.09 Å) Cite: Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. Bioorg.Med.Chem.Lett., 22, 2012

Bcl-Xl与4-(5-丁基-3-(羟甲基)-1-苯基-1H-吡唑-4-基)-3-(3,4-二氢-2(1H)-异喹啉基羰基)-N-((2-(三甲基硅基)乙基)磺酰基)苯甲酰胺复合物的晶体结构
描述符：4-[5-丁基-3-(羟甲基)-1-苯基-1H-吡唑-4-基]-3-(3,4-二氢异喹啉-2(1H)-基羰基)-N-{[2-(三甲基硅基)乙基]磺酰基}苯甲酰胺、Bcl-2样蛋白1（Bcl-2-like protein 1）、咪唑（IMIDAZOLE）
作者：Schroeder, G.M、Wei, D、Banfi, P、Cai, Z、Lippy, J、Menichincheri, M、Modugno, M、Naglich, J、Penhallow, B、Perez, H.L、Sack, J、Schmidt, R.J、Tebben, A、Yan, C、Zhang, L、Galvani, A、Lombardo, L.J、Borzilleri, R.M.
存入日期：2012-04-03
发布日期：2012-06-06
最后修改日期：2024-02-28
测试方法：X射线衍射（分辨率2.09埃（Å））
引用文献：吡唑与嘧啶苯甲酰磺酰胺类作为双重Bcl-2/Bcl-xL拮抗剂。《Bioorg.Med.Chem.Lett.》，第22卷，2012年