Transcripts in the Neurogenic Niche in Neuroinflammatory-Type Schizophrenia

Growing evidence indicates that vascular processes, including blood-brain barrier (BBB) function and angiogenesis, may be altered in schizophrenia and related to neuroinflammation. The subependymal zone (SEZ) neurogenic niche shows reduced neurogenesis markers in schizophrenia that are more pronounced with neuroinflammation. We found changes in the BBB and angiogenesis are more severe in high-inflammation schizophrenia and appear to be linked to reduced neurogenesis in the SEZ. This study underscores the importance of inflammation in shaping vascular and neurogenic pathology in schizophrenia, offering potential pathways for future therapeutic exploration.