Raw Data for: Screening for neurotoxic potential of 15 flame retardants using freshwater planarians

These excel files contain the raw data for each animal and each endpoint. Each excel file contains 1 worksheet for chemical information and another 6 worksheets, named as “Run A”,
“Run B”, “Run C”, “Run D”, “Run E”, “Run F”, which correspond to different plate orientations (See the PDF).

Eighteen chemicals were screened twice in two independent screens, one as a subset of the NTP 87-compound library, which we previously reported on (screen 1; (Zhang et al., 2018)), and the other as a flame retardant library (screen 2). Each screen contained 3 replicate runs with
3 different orientations of concentrations. The 8 animals in one row were exposed to the same concentration. In screen 1, chemical #1 – 8 were screened in 3 replicates of run A, B and C; chemical #9-18 were screened in 3 replicates of run B, D and E (for details, see (Zhang et al.,
2018)). In screen 2, chemical #1 – 8 were screened in 3 replicates of run D, E and F; chemical #9-18 were screened in 3 replicates of run A, C and F.

All worksheets contain the raw data in adult and regenerating (tail) planarians, except that the worksheets in “Eye regeneration - day 7 - FR. xlsx” only contain regenerating planarian data as eyes were not evaluated in full worms. In both sections (regenerating tails and adult worms), each column refers to one chemical, and each row represents one well in the 48-well plate with tested chemical concentrations labeled.

本数据集包含每只动物及每个端点的原始数据。每个 Excel 文件包含一份化学信息工作表，以及六份分别命名为“运行 A”、“运行 B”、“运行 C”、“运行 D”、“运行 E”和“运行 F”的工作表，对应不同的板面取向（见附 PDF 文件）。十八种化学品在两个独立的筛选中各被检测两次，一次作为我们先前报道过的 NTP 87 化合物库的子集（筛选 1；（张等，2018 年）），另一次作为阻燃剂库（筛选 2）。每个筛选包含三个重复运行，每个运行有三种不同的浓度取向。同一行的八只动物暴露于相同的浓度。在筛选 1 中，化学品编号 1-8 在 A、B 和 C 运行的三个重复中进行筛选；编号 9-18 在 B、D 和 E 运行的三个重复中进行筛选（详情见（张等，2018 年））。在筛选 2 中，化学品编号 1-8 在 D、E 和 F 运行的三个重复中进行筛选；编号 9-18 在 A、C 和 F 运行的三个重复中进行筛选。所有工作表均包含成年和再生（尾）扁形动物的原始数据，但“眼再生 - 第 7 天 - FR.xlsx”工作表仅包含再生扁形动物的数据，因为未对完整蠕虫的眼睛进行评估。在再生尾部和成年蠕虫的两个部分中，每列代表一种化学品，每行代表 48 孔板中一个含有测试化学浓度的小孔。