Colorectal cancer (CRC) is a leading cause for cancer related mortality in the western world with a lifetime risk of 6%. Etiology is complex, while genetic background significantly affects the risk. A

NIAID Data Ecosystem90

Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors

淋巴恶性肿瘤

基因功能丧失

Loss of function mutations of the histone acetyltransferase CREBBP have recently been described at high frequencies across a spectrum of lymphoid malignancies. The multiple effects of this epigenetic

干细胞与再生医学数据中心2022-02-20 更新60

A Lack of Premature Termination Codon Read-Through Efficacy of PTC124 (Ataluren) in a Diverse Array of Reporter Assays

无义突变通读

药物机制研究

The drug molecule PTC124 (Ataluren) has been described as a read-through agent, capable of suppressing premature termination codons (PTCs) and restoring functional protein production from genes disrup

Figshare2016-01-18 更新150

Lethal alleles of vital genes from the Zuker collection.

致死等位基因

基因功能丧失

aNew lethal locus in kuz-l(2)34Db interval.bThe hypomorphic alleles tested were l(3)72Ab4, l(3)72Ab16, Hip1472Ad-1, Hip1472Ad-2, Taspase11, Taspase12, ash1B3, HLH1063, HLH1065, HLH1066, HLH1067.

Figshare2015-12-02 更新60

SMI-049 specific SNPs resulting in premature stop codons.

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