Brønsted Acid-Catalyzed Diastereoselective Synthesis of Spiroisoindolinones from Enamides
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https://figshare.com/articles/dataset/Br_nsted_Acid-Catalyzed_Diastereoselective_Synthesis_of_Spiroisoindolinones_from_Enamides/25387014
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资源简介：
A highly diastereoselective synthesis of spiroisoindolinones
from
enamides and 3-hydroxy-isoindolinones is reported. The reaction proceeds
rapidly in the presence of p-toluenesulfonic acid
as a Brønsted acid catalyst and affords a variety of densely
substituted spiroisoindolinones with three contiguous stereogenic
centers in high yields (≤98%) and diastereoselectivities (up
to dr >98:<2:0:0).
创建时间：
2024-03-11
