Brønsted Acid-Catalyzed Diastereoselective Synthesis of Spiroisoindolinones from Enamides
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A highly diastereoselective synthesis of spiroisoindolinones from enamides and 3-hydroxy-isoindolinones is reported. The reaction proceeds rapidly in the presence of p-toluenesulfonic acid as a Brønsted acid catalyst and affords a variety of densely substituted spiroisoindolinones with three contiguous stereogenic centers in high yields (≤98%) and diastereoselectivities (up to dr >98:<2:0:0).
创建时间：
2024-03-11
