Crystal structure of human INPP5K with an allosteric inhibitor reveals the structural basis for species specific potency

Crystal structure of human INPP5K with an allosteric inhibitor reveals the structural basis for species specific potency Descriptor: 1,2-ETHANEDIOL, 2-benzamido-4-phenyl-5-propan-2-yl-thiophene-3-carboxylic acid, Inositol polyphosphate 5-phosphatase K, ... Authors: Nomura, A, Yamaguchi, K, Adachi, T. Deposit date: 2026-01-16 Release date: 2026-03-11 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of human INPP5K with an allosteric inhibitor reveals the structural basis for species specific potency. Sci Rep, 16, 2026携带变构抑制剂的人源INPP5K晶体结构揭示物种特异性效力的结构基础 描述符：1,2-乙二醇、2-苯甲酰胺基-4-苯基-5-异丙基噻吩-3-羧酸、肌醇多磷酸5-磷酸酶K（Inositol polyphosphate 5-phosphatase K，INPP5K）…… 作者：Nomura, A、Yamaguchi, K、Adachi, T. 存入日期：2026-01-16 发布日期：2026-03-11 最后修改日期：2026-04-15 实验方法：X射线衍射（分辨率1.9埃） 引用文献：携带变构抑制剂的人源INPP5K晶体结构揭示物种特异性效力的结构基础。《科学报告》（Sci Rep），16卷，2026年