Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors. Metastatic adrenocortical carcinoma displays higher mutation rate and tumor heterogeneity than primary tumors

We have analyzed 33 human metastatic adrenocortical tumors from 14 patients with advanced metastases and performed whole exome sequencing to identify novel signatures in these tumors. We observed tumor heterogeneity in these tumors coming from the same metastatic tissue site across different patients while the different metastatic tumor sites coming from the same patient are more homogenous in nature.