IL-9 signaling redirects CAR T cell fate toward CD8+ memory and CD4+ cycling states, enhancing anti-tumor efficacy

Il9 signalling CAR-T phenotypes were explored by co-expressing IL9R on CAR-Ts and exposing them to antigen for 10 days followed by scRNA to elucidate the mechanism leading to increased expansion, persistence, and tumor infiltration Overall design: Following chromic antigen exposure, IL9R co expressing CAR-T tells either exposed to IL9 or mock control underwent 10X scRNA sequencing