Association between genetic indexes and the incidence of claw horn lesions and lameness in Holstein cows

Results from additional analysis to accompany Barden M, Anagnostopoulos A, Griffiths BE, Bedford C, Winters M, Li B, Coffey M, Psifidi A, Banos G, Oikonomou G. Association between a genetic index for lameness resistance and the incidence of claw horn lesions in Holstein cows. Vet Rec. 2022 Jul;191(1):e1632. doi: 10.1002/vetr.1632. Epub 2022 Apr 25. PMID: 35468242. Logistic regression models were fit for four outcomes: sole haemorrhage, sole ulcer, white line disease, and lameness. Explanatory variables were parity and herd in addition to each published predicted transmitting ability (PTA) for dairy cows in the UK. Each PTA was fit in separate models, after being scaled to have a unit of one standard deviation. Results are presented at odds ratios with 95% confidence intervals.本附加分析结果配套于下述研究文献：Barden M、Anagnostopoulos A、Griffiths BE、Bedford C、Winters M、Li B、Coffey M、Psifidi A、Banos G、Oikonomou G 所作《荷斯坦奶牛抗跛行遗传指数与蹄角质病变发生率的关联》，刊载于《兽医记录（Veterinary Record, Vet Rec）》，2022年7月，第191卷第1期，文章编号e1632，DOI: 10.1002/vetr.1632，2022年4月25日在线发表，PMID: 35468242。 本研究针对4项结局指标构建logistic回归（Logistic Regression）模型，结局指标分别为蹄底出血、蹄底溃疡、白线病与跛行。解释变量包括胎次、牛群，以及英国奶牛已发表的各预测传递能力（predicted transmitting ability, PTA）；每一项PTA均单独纳入回归模型，且预先经标准化处理使其标准差单位为1。研究结果以比值比（odds ratio, OR）及95%置信区间（confidence interval, CI）形式呈现。