FOXM1 stimulates PLK1 transcription

FOXM1 bound to the MuvB complex (consisting of LIN9, LIN37, LIN52, LIN54 and RBBP4) and MYBL2 (B-MYB) stimulates PLK1 transcription. This creates a positive feedback loop, where PLK1 phosphorylates and activates FOXM1 (Fu et al. 2008), while FOXM1 transcriptional activity results in increased PLK1 levels. MuvB and FOXM1 may persist on the PLK1 promoter throughout G2, while MYBL2 may gradually dissociate from the PLK1 promoter due to proteasome-mediated degradation initiated when MYBL2 is phosphorylated by CCNA (cyclin A)-associated CDKs (Sadasivam et al. 2012).

FOXM1与MuvB复合物（由LIN9、LIN37、LIN52、LIN54和RBBP4组成）以及MYBL2（B-MYB）的结合，刺激PLK1的转录。这形成了一个正反馈回路，其中PLK1通过磷酸化并激活FOXM1（Fu等，2008年），而FOXM1的转录活性导致PLK1水平增加。在G2期，MuvB和FOXM1可能持续存在于PLK1启动子区域，而MYBL2可能在MYBL2被CCNA（周期蛋白A）相关的CDKs（Sadasivam等，2012年）磷酸化后，由于泛素化介导的降解而逐渐从PLK1启动子区域解离。