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The Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly

ChEBI2015-02-27 更新2026-07-21 收录

蛋白质翻译

小分子药物机制

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-65778 数据链接链接失效反馈

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The Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly

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创建时间：

2015-02-27

蛋白质翻译

神经元兴奋性调控

Protein translation is tightly regulated at the initiation phase, which entails exceedingly complex interactions among multiple EIF initiation factors to bring the ribosome to the mRNA and scan the 5’

NIAID Data Ecosystem120

Additional file 4: of Post-translational buffering leads to convergent protein expression levels between primates

基因表达

蛋白质翻译

Ribosome profiling count Table. A .csv file listing raw ribosome profiling counts for genes that are quantifiable across all three species. (CSV 565Â kb)

NIAID Data Ecosystem60

YAP overcomes restriction of translation induced by nutrient deprivation through restoration of mTORC1 activity [293AD]. YAP overcomes restriction of translation induced by nutrient deprivation through restoration of mTORC1 activity [293AD]

Hippo信号通路

蛋白质翻译

The Hippo pathway downstream effectors YAP and TAZ display oncogenic potential via their transcriptional co-activator function, mediated primarily by binding to TEAD transcription factors. Many studie

NIAID Data Ecosystem40

A SIX1/EYA2 small molecule inhibitor disrupts EMT and metastasis

乳腺癌转移

小分子药物机制

This study identified a novel compound reverses SIX1-mediated EMT and metastasis in breast cancer Overall design: RNA-seq was used to identify transcriptional signature that is influenced by SIX1 over

NIAID Data Ecosystem90

Parallel global profiling of plant TOR dynamics reveals a conserved role for LARP1 in protein translation

TOR信号通路

蛋白质翻译

TARGET OF RAPAMYCIN (TOR) is a deeply conserved protein kinase that coordinates eukaryotic metabolism with nutrient availability. In mammals, TOR specifically promotes translation of ribosomal protei

NIAID Data Ecosystem50

The Small Molecule ISRIB Reverses the Effects of eIF2α Phosphorylation on Translation and Stress Granule Assembly

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