HIRA loss transforms FH deficient cells [RNA-Seq]
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP373086
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Purpose: Identifying transcriptional changes led by Hira loss in FH deficient cells Methods: RNA was extracted from the cell lines using QIAGEN kit folloging the manufacturer instructions. RNA concentrator kit was used to guarantee RNA quality. Results/Conclusion: We identified MYC/E2F1 signatures as the top upregulated ones controlling the oncogenic events occuring in Fh1 and Hira deficient cells. Overall design: Transcriptional study of Fh1 proficient cells (Fh1 fl/fl), Fh1 deficient cells (Fh1-/-) and Hira loss through the use of a gRNA (Fh1 fl/fl g1Hira and Fh1-/- g1Hira)
创建时间：
2023-01-31
