Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and (S)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A)

Crystal structure of Bacillus anthracis dihydrofolate reductase complexed with NADPH and (S)-2,4-diamino-5-(3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-ynyl)-6-methylpyrimidine (UCP114A) Descriptor: 5-[(3S)-3-methoxy-3-(3,4,5-trimethoxyphenyl)prop-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Anderson, A.C, Beierlein, J.M, Karri, N.G. Deposit date: 2009-09-18 Release date: 2010-09-15 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (2.57 Å) Cite: Mutational Studies into Trimethoprim Resistance in Bacillus anthracis Dihydrofolate Reductase To be Published

炭疽芽孢杆菌（Bacillus anthracis）二氢叶酸还原酶（dihydrofolate reductase）与烟酰胺腺嘌呤二核苷酸磷酸（NADPH，全称DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE）以及(S)-2,4-二氨基-5-(3-甲氧基-3-(3,4,5-三甲氧基苯基)丙-1-炔基)-6-甲基嘧啶（UCP114A）形成的复合物的晶体结构。描述项：5-[(3S)-3-甲氧基-3-(3,4,5-三甲氧基苯基)丙-1-炔-1-基]-6-甲基嘧啶-2,4-二胺、二氢叶酸还原酶、烟酰胺腺嘌呤二核苷酸磷酸。作者：Anderson, A.C.、Beierlein, J.M.、Karri, N.G.。提交日期：2009年9月18日；发布日期：2010年9月15日；最后修改日期：2023年9月6日。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率2.57埃（Å）。引用文献：《炭疽芽孢杆菌二氢叶酸还原酶甲氧苄啶耐药性突变研究》（待发表）