Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury

Carbon tetrachloride (CCl4), Concanavalin A (ConA), bile duct ligation (BDL), and liver resection (LR) are four types of commonly used acute liver injury mice models. There is a lack of investigation summarizing multiple organ changes in these four models and exploring the intrinsic molecular mechanism systematically. In the current study, transcriptomic changes of multiple organs (heart, lung, kidney, spleen, brain) were investigated to analyze the systematic changes in theses four commonly used acute liver injury mice models. Our study provide guidance for application of the four acute liver injury mice models in research. Furthermore, the present study helps to better understand the influence of acute liver injury on extra-liver organs at the early stage and the potential crosstalk between liver and extra-liver organs.