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PRKDC, the catalytic subunit of DNA-dependent protein kinase, regulates EWS-FLI1 stability

NIAID Data Ecosystem2026-03-10 收录

尤文肉瘤分子机制

EWS-FLI1蛋白稳定性调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE93076 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

应用场景：

创建时间：

2018-08-13

尤文肉瘤分子机制

转录组学分析

The purpose of this study was to determine the transcriptional regulatory similarities and differences in the FET/ETS translocations that have been identified as drivers of Ewing sarcoma. Overall desi

NIAID Data Ecosystem50

Supplementary Table S6 from KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma

尤文肉瘤分子机制

表观遗传调控

Excel file showing DEG and downregulated direct targets upon KDM6A or KDM6B knockout.

Figshare2025-11-14 更新40

EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq). EWSR1::FLI1 fusion oncoproteins’ regulation of ETS1 (RNA-seq)

尤文肉瘤分子机制

肿瘤转移调控

Ewing sarcomas harbor few mutations beyond the chromosomal translocation that initiates disease and the mechanistic basis for the metastasis of these tumors remains poorly understood. The epigenome of

NIAID Data Ecosystem20

EWS::FLI cooperatively binds at GGAA microsatellites via DBD-a4 helix in TTC-466 [H3K27ac_CnT]

尤文肉瘤分子机制

转录组调控

Multi-omics study of DBD-a4 helix of EWS::FLI to understand the underlying mechanism of transcriptional regulation in Ewing sarcoma cell line: TTC-466 In TTC-466 cells, we knock-down endogenous EWSR1:

NIAID Data Ecosystem40

EWS-FLI1 and HOXD13 control tumor cell plasticity in Ewing sarcoma [CUT&RUN]

尤文肉瘤分子机制

表观遗传调控

Posterior homeobox D genes, in particular HOXD13, are over-expressed by Ewing sarcoma, a tumor driven by the oncogenic fusion protein EWS-FLI1. Here, we have found that EWS-FLI1 maintains HOXD13 expre

NIAID Data Ecosystem30

PRKDC, the catalytic subunit of DNA-dependent protein kinase, regulates EWS-FLI1 stability

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