Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of Five Potent 5-(omega-Carboxy(alkyloxy)Pyrido[2,3-d]pyrimidine Derivatives
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Structural Analysis of Pneumocystis carinii and Human DHFR Complexes with NADPH and a Series of Five Potent 5-(omega-Carboxy(alkyloxy)Pyrido[2,3-d]pyrimidine Derivatives Descriptor: Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ethyl 4-{3-[(2,4-diamino-5-methylpyrido[2,3-d]pyrimidin-6-yl)methyl]-4-methoxyphenoxy}butanoate Authors: Cody, V. Deposit date: 2010-07-16 Release date: 2010-12-29 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural analysis of Pneumocystis carinii and human DHFR complexes with NADPH and a series of five potent 6-[5'-([omega]-carboxyalkoxy)benzyl]pyrido[2,3-d]pyrimidine derivatives Acta Crystallogr.,Sect.D, 67, 2011
卡氏肺孢子虫与人类二氢叶酸还原酶（Dihydrofolate reductase，DHFR）结合烟酰胺腺嘌呤二核苷酸磷酸（NADPH）及五种强效5-(ω-羧基(烷氧基)吡啶并[2,3-d]嘧啶)衍生物的复合物结构分析
描述符：二氢叶酸还原酶（Dihydrofolate reductase）、烟酰胺腺嘌呤二核苷酸磷酸（NADPH）、4-{3-[(2,4-二氨基-5-甲基吡啶并[2,3-d]嘧啶-6-基)甲基]-4-甲氧基苯氧基}丁酸乙酯
作者：科迪（Cody, V.）
提交日期：2010-07-16
发布日期：2010-12-29
最后修改日期：2023-09-06
实验方法：X射线衍射（分辨率1.8埃）
引用文献：卡氏肺孢子虫与人类二氢叶酸还原酶结合烟酰胺腺嘌呤二核苷酸磷酸及五种强效6-[5'-(ω-羧基烷氧基)苄基]吡啶并[2,3-d]嘧啶衍生物的复合物结构分析，《晶体学报》D辑，67卷，2011年
创建时间：
2010-07-16
