Fibrosis and atrial fibrillation in Scn1b null mice

Scn1b-/- mice are a model of Early Infantile Developmental Epileptic Encephalopathy (EIDEE). These mice exhibit characteristic seen in patients such as spontaneous siezures, ataxia, growth abnormalites, and a high incidence of premature mortality. The goal of this study was to identify changes in gene expression between Scn1b wild-type and Scn1b-/- mice in the atria RNA-Seq in cardiac atrial tissue from 16-day old wild type (WT) and Scn1b-/- mice