Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156

Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1156 Descriptor: (2R,3S,4R)-3-(4-hydroxyphenyl)-4-methyl-2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}-3,4-dihydro-2H-1-benzopyran-7-ol, Estrogen receptor Authors: Fanning, S.W, Hodges-Gallager, L, Myles, D.C, Sun, R, Fowler, C.E, Green, B.D, Harmon, C.L, Greene, G.L, Kushner, P.J. Deposit date: 2018-01-11 Release date: 2018-02-14 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (1.997 Å) Cite: Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity. Nat Commun, 9, 2018

雌激素受体α（Estrogen Receptor Alpha）配体结合域与OP1156的复合物 描述：(2R,3S,4R)-3-(4-羟基苯基)-4-甲基-2-{4-[2-(吡咯烷-1-基)乙氧基]苯基}-3,4-二氢-2H-1-苯并吡喃-7-醇，该复合物的结合靶点为雌激素受体。作者：Fanning, S.W、Hodges-Gallager, L、Myles, D.C、Sun, R、Fowler, C.E、Green, B.D、Harmon, C.L、Greene, G.L、Kushner, P.J。提交日期：2018-01-11；发布日期：2018-02-14；最后修改日期：2023-10-04。检测方法：X射线衍射（X-RAY DIFFRACTION），分辨率为1.997埃（Å）。引用文献：OP-1074的特定立体构型可破坏雌激素受体α的12号螺旋并赋予纯粹的抗雌激素活性，《自然·通讯》（Nat Commun），第9卷，2018年。