Maternal age and Offspring DNA methylation (for manuscript: Yeung et al. Maternal age is related to offspring DNA methylation: A meta-analysis of results from the PACE consortium. Aging Cell 2024; PMID: 38808605)

Data sharing file (DSF) 1, 2, and 3. Meta-analyses of single CpG associations from the set of Illumina 450K microarray probes between maternal age at birth (in years) with newborn blood DNA methylation. Meta-analyses of results from robust linear regression models adjusting for 3 separate sets of covariates: 1) minimal adjustment for cell type estimation, batch, and selection (as applicable from each cohort), 2) main adjustment for cell type estimation, maternal smoking, maternal education, maternal race/ethnicity/ancestry, parity, batch, and selection (as applicable from each cohort), 3) BMI adjustment for above + maternal BMI. Using model 2 covariates, DSF4-7 shows results for: 4) childhood DNA methylation, 5) newborn DNA methylation using EPIC microarray, 6) newborn DNA methylation additionally adjusting for sex, and 7) childhood DNA methylation additionally adjusting for sex.Direction of associations correspond to the cohorts providing data in the following order: EAGeR, Gen3G, DCHS, ALSPAC, NORTHPOP, GenR, POSEIDON, EARLI, MARBLES, CHAMACOS, INMA, MoBa1, MoBa2, MoBa4, MoBa8, Upstate KIDS, CHS. In BMI models, NORTHPOP was dropped. Childhood DNA methylation cohorts were included: Upstate KIDS, HELIX, MMNP, PMMST. More details about each cohort are provided in supplementary materials with the publication.pval_FDR and HetPVAL_FDR are FDR p-values corrected for multiple testing for the CpG associations and the heterogeneity of the associations between the cohorts contributing data in the meta-analysis, respectively.Citation: "Maternal age is related to offspring DNA methylation: A meta‐analysis of results from the PACE consortium" Aging Cell 2024