Gene expression profiling to identify potential therapeutic targets and improve prognostication of advanced penile squamous cell carcinoma. Homo sapiens

Advanced penile squamous cell carcinoma (PSCC) receiving first-line chemotherapy, visceral metastases (VM) and ECOG performance status ≥ 1 are poor prognostic factors for overall survival (OS). We hypothesized that tumor gene expression profiling may enhance prognostic stratification and identify potential therapeutic targets. Overall design: We performed tumor tissue NanoString analysis of 25 patients with locally advanced or metastatic PSCC receiving first-line cisplatin-based chemotherapy to identify a prognostic gene expression signature after controlling for VM and PS status.