Alteration of cell proliferation and apoptosis in GST-P⁺ foci and surrounding liver tissue, 8-OHdG formation and GABA(A)RA1/GST-P⁺ foci numbers in the livers of rats treated with DEN or vehicle (saline) and administered Valerian at doses of 50, 500 and 5000 ppm.

Data are Mean ± SD; aP<0.05; bP<0.01; cP<0.001; dP<0.0001 vs DEN control group; e(n = 10) for DEN, DEN→Val, 50 ppm, DEN→Val, 500 ppm, DEN→Val, 5000 ppm, Vehicle→Val, 5000 ppm groups and (n = 9) for Vehicle control group. *P<0.05 and **P<0.01 vs vehicle control group; ND: not detected. Alteration of cell proliferation and apoptosis in GST-P+ foci and surrounding liver tissue, 8-OHdG formation and GABA(A)RA1/GST-P+ foci numbers in the livers of rats treated with DEN or vehicle (saline) and administered Valerian at doses of 50, 500 and 5000 ppm.