Mouse retina single-cell RNA-seq of WT and two Nr2e3 mutant models to explore the role of Nr2e3 in cone and rod photoreceptor differentiation

Single-cell RNA-seq of mouse WT retinas and two Nr2e3 mutant retinas, ?27 and ?E8 (containing a 27 nucleotide in-frame deletion or a complete exon 8 deletion, respectively). The ?27 retinas were used as a model for enhanced S-cone syndrome phenotype in humans, while the ?E8 retinas show a progressive retinal degeneration similar to human retinitis pigmentosa patients. This data was used to explore the role of Nr2e3 in cone and rod photoreceptor differentiation.