DNA甲基化和microRNA表达的整合分析揭示了肝细胞癌中差异的机制[RNA-Seq]
收藏干细胞与再生医学数据中心2023-02-10 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=900c8f785d024771966c507c0f18e04b
下载链接
链接失效反馈官方服务：
资源简介：
We evaluate the epigenetic mechanisms of racial disparity in HCC through an integrated analysis of DNA methylation, miRNA, and combined regulation of gene expression. Specifically, we acquired DNA methylation, mRNA-seq, and miRNA-seq data through the analysis of tumor and adjacent normal liver tissues from African Americans (AA) and European Americans (EA) with HCC.
Results: Using mixed ANOVA, we identified cytosine-phosphate-guanine (CpG) sites, mRNAs, and miRNAs that are statistically significantly altered in HCC vs. adjacent normal in a race-specific manner. Through integrative analysis, we identified significantly differentially expressed genes in HCC with disparate epigenetic regulation, associated with changes in miRNA expression for AA and DNA methylation for EA.
创建时间：
2023-02-10
