NSD2864

Dengue fever is the most rapidly spreading arboviral disease in the world causing an estimated 390 million infections and 22,000 deaths annually in at least 100 countries. There is currently no cure and no licensed vaccine available. Disease prevention is done by mosquito vector control. Outbreaks occur periodically in most endemic countries, but outbreak detection is usually not accurate or timely enough to initiate control interventions in time. This project aims to contribute to the development of early warning systems for dengue epidemics by evaluating entomological and immunological indices that accurately represent dengue transmission and evaluate the impact of vector control interventions. Specifically, the project will assess the relationship between proposed indices and dengue incidence using vector density, vector infectivity, and human exposure to mosquitoes; and to assess the validity of the these indices in evaluating the impact of vector control interventions.