ADRC Data Freeze Ending 2025-03-31

The Knight Alzheimer Disease Research Center (ADRC) Data Freeze Ending 2025-03-31 is a longitudinal compilation of harmonized, processed research data collected from August 1, 1979 through March 31, 2025. This Data Freeze represents a fixed, versioned snapshot of curated datasets maintained by the ADRC and is intended to support reproducible secondary analyses under approved data use agreements.

The Data Freeze includes data contributed by multiple ADRC Cores, including clinical assessments, cognitive testing, neuropsychological measures, neuroimaging data summaries, fluid biomarker data, neuropathology variables, and related research measures. Modules are compiled, quality controlled, and integrated according to ADRC Data Management and Sharing procedures prior to freeze finalization.

This dataset reflects the full longitudinal structure of ADRC participant data available as of the official cutoff date (March 31, 2025). No data collected after this date are included in this release. Each subsequent Data Freeze constitutes a new versioned dataset with its own DOI.

The purpose of this Data Freeze is to:
1. Provide a stable, citable dataset snapshot for approved secondary analyses
2. Support NIH Data Management and Sharing (DMS) policy compliance
3. Enable transparency, reproducibility, and longitudinal tracking of dataset versions

This repository record provides metadata describing the Data Freeze and assigns a persistent DOI to this version. The underlying human subject data are stored in a secure Research Infrastructure Services (RIS) environment and are not publicly downloadable.

Access to this dataset is controlled and requires submission of a formal data request through the Knight ADRC Request Center. Approved investigators must complete the appropriate Data Use Agreement prior to receiving access. Upon approval, access to the static dataset corresponding to this DOI will be granted through ADRC-managed secure infrastructure.

Investigators using this Data Freeze must cite this dataset DOI in all resulting publications and acknowledge Knight ADRC funding as specified in the Data Use Agreement.

This dataset was generated and curated by the Knight ADRC Data Management and Statistics Core in collaboration with contributing ADRC Cores.

For information about submitting a data request, please visit: https://knightadrc.wustl.edu/professionals-clinicians/request-center-resources/submit-a-request/