Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity

These tissue were harvested to complement and extend the studies that generated GSE23093. They served 3 purposes; 1) identify genes important to choroid plexus function and compare them with those important for meninges and associated vasculature (MAV) function, 2) determine genes in the choroid plexus and sensitivity hyperthermia and amphetamine toxicity, 3) identify the important gene expression changes related to the immune system in MAV, choroid plexus and trunk' blood本研究采集的组织用于补充并拓展生成GSE23093数据集的相关研究。本研究设定三项核心目标：1）筛选与脉络丛（choroid plexus）功能密切相关的基因，并将其与脑膜及相关脉管系统（MAV）功能相关的基因进行对比；2）明确脉络丛中与高温敏感性及苯丙胺（amphetamine）毒性相关的基因；3）筛选脑膜及相关脉管系统、脉络丛与躯干血液中与免疫系统相关的关键基因表达变化。