PK-PD TBAJ-587 study mutants

NIAID Data Ecosystem2026-05-10 收录

抗结核药物PK/PD

结核分枝杆菌耐药性

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP682772 数据链接链接失效反馈

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资源简介：

Aguilar-Ayala et al. In-vitro pharmacokinetics and pharmacodynamics of the diarylquinoline TBAJ-587 and its metabolites against Mycobacterium tuberculosis

创建时间：

2026-03-11

Impact of mutations in rv2887, putative transcriptional repressor, on gene expression in Mycobacterium tuberculosis.. Mycobacterium tuberculosis

结核分枝杆菌耐药性

细菌转录组学

This study was aimed towards understanding the consequences of mutating rv2887, a putative transcriptional repressor, on gene expression in Mycobacterium tuberculosis. Since clones carrying mutations

NIAID Data Ecosystem50

Mutations in the rpoB Gene of Rifampin-Resistant Mycobacterium tuberculosis Isolates in Spain and Their Rapid Detection by PCR–Enzyme-Linked Immunosorbent Assay

结核分枝杆菌耐药性

分子诊断

Genetic alterations in the rpoB gene were characterized in 50 rifampin-resistant (Rif(r)) clinical isolates of Mycobacterium tuberculosis complex from Spain. A rapid PCR–enzyme-linked immunosorbent as

PubMed Central20

Mycobacterium tuberculosis subsp. tuberculosis Genome sequencing. Mycobacterium tuberculosis subsp. tuberculosis

结核分枝杆菌耐药性

基因组流行病学

To understand transcontinental spread of MDR M. tuberculosis and the relative contributions of acquired and transmitted drug resistance, we studied WTK, a lineage 2 Mycobacterium tuberculosis strain c

NIAID Data Ecosystem20

Top 10 upregulated proteins of the BDQ-resistant strains EH3.6 and EH 3.2 compared to EH3.0.

结核分枝杆菌耐药性

差异表达蛋白质分析

Proteins displaying the highest differential upregulation factors (top 10 proteins) are indicated. The descriptions of the genes were retrieved from TubercuList (http://tuberculist.epfl.ch/).

NIAID Data Ecosystem40

Mycobacterium tuberculosis Genome sequencing. Mycobacterium tuberculosis

结核分枝杆菌耐药性

结核病基因组学

Tuberculosis has posed a serious threat to human health. It is imperative to investigate the geographic prevalence of tuberculosis and medication resistance, as this information is essential for infor

NIAID Data Ecosystem20

PK-PD TBAJ-587 study mutants

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