Comparison of activity of compounds tested by incubating naturally acquired and cultured gametocytes.

The inhibitory concentration (IC50) is presented for compounds that were incubated for 24 hours with gametocytes from naturally infected gametocyte carriers (field isolates) or cultured NF54 gametocytes (NF54). IC50 values are based on Fig 3 for field isolates or on published data with cultured NF54 gametocytes from the same study team. Alongside these IC50 values in mosquito feeding assays, IC50 values from NF54 gametocyte viability assays are presented. ND = not done; * = data taken from [21]; ** = data taken from [33]. Experiments with no infected mosquitoes in the DMSO control were not included in the dose response analyses.