data in brief_γ-Tocotrienol Suppresses Cervical Cancer HeLa Cell Growth via Downregulation of the PI3K/AKT/mTOR Signalling Pathway

The file is a Data in Brief used by Xu et al study for further elucidating the anti-cervical cancer mechanism of γ-Tocotrienol (γ-T3) in vitro. The data showed that γ-T3 inhibited the PI3K/AKT/mTOR pathway in human cervical cancer HeLa cells by suppressing both upstream regulators and downstream effectors, including PI3K, AKT, mTOR, p70S6K, 4E-BP1, c-Myc, and cyclin D1. These inhibitory effects result in reduced proliferation, G0/G1 cell cycle arrest, and increased apoptosis. The action of γ-T3 was comparable to WM, and their combination showed enhanced efficacy, further supporting this pathway as its primary target.本数据集为Xu等人研究中所用的《数据简报》（Data in Brief）类数据，用于进一步阐明γ-生育三烯酚（γ-Tocotrienol, γ-T3）的体外抗宫颈癌作用机制。实验数据显示，γ-T3可通过抑制人宫颈癌细胞海拉（HeLa）细胞内PI3K/AKT/mTOR通路（PI3K/AKT/mTOR pathway）的上游调控因子与下游效应分子（包括PI3K、AKT、mTOR、p70核糖体S6激酶（p70S6K）、真核翻译起始因子4E结合蛋白1（4E-BP1）、c-Myc及细胞周期蛋白D1（cyclin D1）），阻断该通路。上述抑制效应可导致细胞增殖能力下降、G0/G1期细胞周期阻滞以及凋亡水平升高。γ-T3的作用效果与WM相当，二者联合使用时疗效进一步增强，从而进一步证实该通路为γ-T3的核心作用靶点。