Potentiation of MEKi efficacy by the estrogen receptor antagonist Fulvestrant in ERα-positive cancer cell lines.
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The predicted additive effect was determined by applying the Bliss additivity model§[25]. A greater than additive or synergistic interaction (observed effect exceeds the expected effect) was noted only in the ERα- expressing cell lines, SKOV3 and Ishikawa. Conversely, A2780, ERα-negative ovarian carcinoma cells exhibited antagonism between MEKi and fulvestrant.¶As determined by SRB assay.
创建时间：
2015-12-02
