NLGNs binds PSD-95 subfamily members

Neuroligins (NLGNs) bind to the third PDZ domain of postsynaptic density (PSD)-95 whereas NMDA receptor and K+ channels interact with the first and the second PDZ domains. The cytoplasmic domains of all three neuroligins interacts with the NH2-terminus of PSD-95 and its homologs PSD-93 and SAP102, which contains the three PDZ domains (Irie et al. 1997).

神经连接蛋白（NLGNs）与突触后密度（PSD-95）的第三PDZ结构域结合，而NMDA受体和K+通道则分别与第一和第二个PDZ结构域相互作用。所有三种神经连接蛋白的细胞质结构域与PSD-95及其同源蛋白PSD-93和SAP102的NH2端结合，这些蛋白含有三个PDZ结构域（Irie等，1997年）。